BM0010

Ifetroban sodium

≥98% (HPLC)

• Synonym(s): 2-[[(1S,2R,3S,4R)-3-[4-[(Pentylamino)carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]-benzenepropanoic acid sodium salt, BMS 180291-02, BMS-180291 sodium, Sodium ifetroban
• Empirical Formula (Hill Notation): C₂₅H₃₁N₂O₅ · Na
• CAS Number: 156715-37-6
• Molecular Weight: 462.51
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774354

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: [O-]C(CCC1=C(C[C@H]2[C@@H](O3)CC[C@@H]3[C@H]2C4=NC(C(NCCCCC)=O)=CO4)C=CC=C1)=O.[Na+]
• InChI: 1S/C25H32N2O5.Na/c1-2-3-6-13-26-24(30)19-15-31-25(27-19)23-18(20-10-11-21(23)32-20)14-17-8-5-4-7-16(17)9-12-22(28)29;/h4-5,7-8,15,18,20-21,23H,2-3,6,9-14H2,1H3,(H,26,30)(H,28,29);/q;+1/p-1/t18-,20-,21+,23-;/m0./s1
• InChI key: WOHSQDNIXPEQAE-QBKVZTCDSA-M

Description

Biochem/physiol Actions

Ifetroban (BMS-180291) is a potent and selective thromboxane receptor antagonist.

Ifetroban (BMS-180291) is a potent and selective thromboxane receptor antagonist. The IC₅₀ for inhibition of arachadonate or U-46619-induced platelet aggregation in human plasma is 7 nM and 30 nM, respectively. Ifetroban inhibits platelet aggregation in African green monkey 100% at 3 mpk, and blocks the contractile effects of U-46619 and Ang II in rabbit renal afferent arterioles.

Features and Benefits

Ifetroban is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable