BM0008

BMS-214662 hydrochloride

≥98% (HPLC)

• Synonym(s): (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine hydrochloride, BMS 214662
• Empirical Formula (Hill Notation): C₂₅H₂₃N₅O₂S₂ · HCl
• CAS Number: 195981-08-9
• Molecular Weight: 526.07
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774353

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=S(N1CC(C=C(C#N)C=C2)=C2N(CC3=CN=CN3)C[C@H]1CC4=CC=CC=C4)(C5=CC=CS5)=O.[H]Cl
• InChI: 1S/C25H23N5O2S2.ClH/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22;/h1-11,14,18,23H,12,15-17H2,(H,27,28);1H/t23-;/m1./s1
• InChI key: LBPFLNDUCNNGPS-GNAFDRTKSA-N

Description

General description

BMS-214662 is a small molecule inhibitor containing an imidazole tetrahydro benzodiazepine and without thiol and peptide attached.

Biochem/physiol Actions

BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase that reduces Ras prenylation in NF90-8 and ST88-14 sheath tumor (MPNST) cell lines. BMS-214662 induces apoptosis in cancer cell lines, and potently inhibits growth of human tumor xenografts.

BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase.

It competes with other inhibitors for Ras protein substrate during inhibition of farnesyltransferase.

Features and Benefits

BMS-214662 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable