BM0001

BMS-341400 methanesulfonate

≥98% (HPLC)

• Synonym(s): 1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3H-pyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-N-methyl-H-imidazole-4-carboxamide methanesulfonate (1:1), 1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3Hpyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-4-methylimidazolecarboxamide methanesulfonate
• Empirical Formula (Hill Notation): C₂₃H₂₂ClN₉O₂ · CH₄O₃S
• CAS Number: 296250-54-9
• Molecular Weight: 588.04
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774349

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: O=S(C)(O)=O.ClC1=CC(CNC2=C(C(C=NN3CC)=C3N=C4)C4=C(N5C=NC(C(NC)=O)=C5)N=N2)=CC=C1OC
• InChI: 1S/C23H22ClN9O2.CH4O3S/c1-4-33-21-15(10-29-33)19-14(9-27-21)22(32-11-17(28-12-32)23(34)25-2)31-30-20(19)26-8-13-5-6-18(35-3)16(24)7-13;1-5(2,3)4/h5-7,9-12H,4,8H2,1-3H3,(H,25,34)(H,26,30);1H3,(H,2,3,4)
• InChI key: NTAGDQYHYAUFMS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BMS-341400 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor.

BMS-341400 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor. BMS-341400 has an IC₅₀ value of 0.3 nM and is 150-fold selective for PDE5 over PDE6 and over 10,000-fold selective for PDE5 over PDE1, PDE2, PDE3, and PDE4.

Features and Benefits

BMS-341400 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable