B9685

BAY 61-3606 hydrochloride hydrate

≥98% (HPLC), powder

• Synonym(s): 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride
• Empirical Formula (Hill Notation): C₂₀H₁₈N₆O₃ · xHCl · yH₂O
• Molecular Weight: 390.40 (anhydrous free base basis)
• MDL number: MFCD29073361
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724427
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• potency: 7.5 nM K_i
• storage condition: desiccated
• color: yellow
• solubility: H₂O: soluble
• originator: Bayer
• storage temp.: 2-8°C
• SMILES string: O.Cl.COc1ccc(cc1OC)-c2cc3nccn3c(Nc4ncccc4C(N)=O)n2
• InChI: 1S/C20H18N6O3.ClH.H2O/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H;1H2
• InChI key: WYXPKEXHEJAVSI-UHFFFAOYSA-N

Description

Application

BAY 61-3606 hydrochloride hydrate has been used in focal cerebral ischemia model.[1] It has also been used to assess the effect of Syk in stroke-induced injury.[2]

Biochem/physiol Actions

BAY 61-3606 helps to prevent the degranulation of freshly isolated basophils. It also prevents B cell receptor (BCR)-mediated signaling.[3]

Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)