B9678
Monoclonal Anti-Bone Morphogenetic Protein 4 antibody produced in mouse
clone 66119.11, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-BMP-4
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About This Item
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
66119.11, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
neutralization: suitable
western blot: 1-2 μg/mL
isotype
IgG2b
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... BMP4(652)
General description
Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage, hematopoietic cell formation and mesoderm patterning. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. Among the BMPs, BMP-4 has major role in mammalian hematopoiesis, formation of mesoderm, myogenesis and differentiation of embryonic stem cells. BMP-4 signaling involves activation of major pathways such as Hedgehog and Wnt signaling.. Monoclonal Anti-BMP-4 recognizes human BMP-4. The antibody shows ~5% cross reactivity with recombinant human BMP-2, recombinant mouse BMP RIA, and recombinant mouse BMP-RIB.
Specificity
The antibody shows approximately 5% cross-reactivity with recombinant human BMP-2, mouse BMP RIA, and mouse BMP RIB.
Immunogen
recombinant monomeric human BMP-4 expressed in NSO cells.
Application
The antibody is suitable for neutralization assays at a working concentration of 1-3 μg/ml (ND50).
Physical form
Lyophilized from a 0.2 μm filtered solution in in phosphate buffered saline with 5% trehalose.
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Timothy J Sadlon et al.
Stem cells (Dayton, Ohio), 22(4), 457-474 (2004-07-28)
Blood formation occurs throughout the life of an individual in a process driven by hematopoietic stem cells (HSCs). The ability of bone marrow (BM) and cord blood (CB) HSC to undergo self-renewal and develop into multiple blood lineages has made
P C Bessa et al.
Journal of tissue engineering and regenerative medicine, 2(1), 1-13 (2008-02-23)
Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-beta (TGFbeta) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various
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Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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