B8554
Anti-Bax antibody, Mouse monoclonal
clone 2D2, purified from hybridoma cell culture
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About This Item
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biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2D2, monoclonal
form
buffered aqueous solution
mol wt
antigen 21 kDa (and possibly a dimer of 42 kDa)
species reactivity
human, bovine
should not react with
rat, mouse
concentration
~2 mg/mL
technique(s)
microarray: suitable
western blot: 1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... BAX(581)
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General description
Bax is a tumor suppressor that belongs to the Bcl-2 family and modulates cellular apoptosis. Bax is regulated by p53 and increased Bax levels have been associated with cell death stimuli. Alterations in Bax have been linked to several neurological diseases and cancers [1]. Monoclonal Anti-Bax antibody is specific for the epitope within amino acids 3-16 of the human Bax protein. The antibody reacts with Bax in bovines and humans, but not in mice and rats.
Immunogen
synthetic peptide corresponding to amino acids 3-16 of the human Bax sequence, conjugated to KLH.
Application
Monoclonal Anti-Bax antibody is suitable for use in western blot (1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone) and microarray.
Physical form
Solution in phosphate bufered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Bing Z Carter et al.
Haematologica, Online ahead of print (2020-12-24)
MCL-1 and BCL-2 are both frequently overexpressed in acute myeloid leukemia and critical for the survival of acute myeloid leukemia cells and acute myeloid leukemia stem cells. MCL-1 is a key factor in venetoclax resistance. Using genetic and pharmacological approaches
H J Brady et al.
The international journal of biochemistry & cell biology, 30(6), 647-650 (1998-08-08)
Bax is a pro-apoptotic member of the Bcl-2 family of genes which regulate programmed cell death. The Bax protein shares highly conserved domains with Bcl-2, some of which are required for the formation of Bax-Bcl-2 heterodimers. Bax expression is elevated
Elizabeth S Henson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(3 Pt 1), 845-853 (2006-02-10)
Monoclonal antibodies, such as herceptin and trastuzumab, against the epidermal growth factor receptor ErbB2 (also known as HER2/neu) are an effective therapy for breast cancer patients with overexpression of ErbB2. Herceptin, in combination with standard chemotherapy, such as taxol or
L Lalier et al.
Oncogene, 26(34), 4999-5009 (2007-03-21)
Prostaglandin E(2) plays multiple roles both in the physiology and the physiopathology of human brain, which are not completely understood. We have identified in a subset of human glioblastoma multiforme (GBM) tumors, the most common form of adult brain cancer
G Basañez et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(10), 5492-5497 (1999-05-13)
Release of proteins through the outer mitochondrial membrane can be a critical step in apoptosis, and the localization of apoptosis-regulating Bcl-2 family members there suggests they control this process. We used planar phospholipid membranes to test the effect of full-length
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