B2430
Monoclonal Anti-Betacellulin antibody produced in mouse
clone 34362.11, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-BTC
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About This Item
MDL number:
UNSPSC Code:
51111800
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
34362.11, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
capture ELISA: suitable
western blot: suitable
isotype
IgG1
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... BTC(685)
General description
βcellulin (BTC) is a growth factor that belongs to the epidermal growth factor (EGF) family. BTC is the product of post-translational modification of a larger membrane-anchored precursor peptide. A wide range of tissues including liver, kidney, pancreas and small intestine highly express BTC. The main function of BTC is the regulation of growth, proliferation, regeneration and differentiation of pancreatic β cells. It also has important physiological role in the development and function of endocrine precursor cells of pancreas. The cellular effects of BTC are mediated by the EGF receptors, Erb-1, -2, -3 and -4. The pathways mediated by the binding of BTC to Erbs are Ras/MAPK and PI3K pathways. βcellulin has been reported to also drive proliferation of osteoblasts and neural stem cells and increase cortical bone deposition and neurogenesis, respectively
Monoclonal Anti-βcellulin (BTC) recognizes human βcellulin. This antibody exhibits no cross-reactivity with recombinant human EGF, HB-EGF, TGF-a, HRG-a, and AR in immunoblotting.
Monoclonal Anti-βcellulin (BTC) recognizes human βcellulin. This antibody exhibits no cross-reactivity with recombinant human EGF, HB-EGF, TGF-a, HRG-a, and AR in immunoblotting.
Immunogen
recombinant human betacellulin (BTC)
Application
Anti-βcellulin antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. The antibody is suitable for ELISA at a recommended concentration of 1-2 μg/ml.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Preparation Note
Purified using protein A.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Y Yarden et al.
Nature reviews. Molecular cell biology, 2(2), 127-137 (2001-03-17)
When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer
María Victoria Gómez-Gaviro et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(4), 1317-1322 (2012-01-11)
Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain, including the subventricular zone and the dentate gyrus, which act to control NSC behavior. Among other cell types within these niches, NSCs are found in close proximity
Damian C Genetos et al.
Cell and tissue research, 340(1), 81-89 (2010-02-19)
Cellular signaling via epidermal growth factor (EGF) and EGF-like ligands can determine cell fate and behavior. Osteoblasts, which are responsible for forming and mineralizing osteoid, express EGF receptors and alter rates of proliferation and differentiation in response to EGF receptor
Yoon Sin Oh et al.
PloS one, 6(8), e23894-e23894 (2011-09-08)
Betacellulin (BTC), a member of the epidermal growth factor family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. Growth-promoting actions of BTC are mediated by epidermal growth factor receptors (ErbBs), namely ErbB-1
A J Dunbar et al.
The international journal of biochemistry & cell biology, 32(8), 805-815 (2000-08-15)
Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. BTC was initially described, purified and
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