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B1814

Sigma-Aldrich

Bone Morphogenetic Protein 2 human

Carrier Free, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

BMP-2

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About This Item

MDL number:
MFCD03097877
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

26 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin, tested

color

white

solubility

water: soluble 0.100 mL, clear, colorless

UniProt accession no.

P12643

storage temp.

−20°C

Gene Information

human ... BMP2(650)

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Biochem/physiol Actions

Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution.

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

104.0 °F - closed cup

flash_point_c

40.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
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Journal of biomedical materials research. Part B, Applied biomaterials, 103(7), 1344-1353 (2014-11-12)
Repair of cartilage-bone interface tissue remains challenging, because it combines different cell types and gradients of composition and properties. To enable simultaneous regeneration of bone, cartilage, and especially their interface, a conically graded scaffold of chitosan-gelatin hydrogel/poly(l-lactide-co-glycolide) (PLGA) was facilely
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Journal of periodontal & implant science, 45(3), 101-110 (2015-07-02)
Sclerostin, an inhibitor of Wnt/β-catenin signaling, exerts negative effects on bone formation and contributes to periodontitis-induced alveolar bone loss. Recent studies have demonstrated that serum sclerostin levels are increased in diabetic patients and that sclerostin expression in alveolar bone is
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