B1793
Bafilomycin A1
from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
2 μg | Estimated to ship TODAYfromMILWAUKEE | $95.60 |
10 μg | Estimated to ship TODAYfromMILWAUKEE | $232.00 |
About This Item
Product Name
Bafilomycin A1 from Streptomyces griseus, ≥90% (HPLC)
Quality Segment
assay
≥90% (HPLC)
form
film
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
−20°C
SMILES string
CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C
InChI
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
General description
Application
- as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes
- as a vacuolar-type H+ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells[1]
- as a vacuolar-type H+ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells[2]
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥90% (HPLC) | assay ≥95% (HPLC) | assay ≥90% total oligomycins basis (HPLC) | assay - |
| form film | form powder | form powder | form - |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| antibiotic activity spectrum fungi | antibiotic activity spectrum fungi, yeast | antibiotic activity spectrum fungi | antibiotic activity spectrum Gram-positive bacteria |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action enzyme | inhibits, protein synthesis | interferes | mode of action enzyme | inhibits | mode of action protein synthesis | interferes |
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Storage Class
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