B1184

BCMA/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• Synonym(s): B cell maturation
• MDL number: MFCD03456173
• UNSPSC Code: 51111800

Properties

• biological source: human
• recombinant: expressed in NSO cells
• assay: >95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.01-0.04 μg/mL ED₅₀
• mol wt: 35-45 kDa by SDS-PAGE (reducing); calculated mol wt 32 kDa
• storage condition: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• impurities: endotoxin, tested
• UniProt accession no.: Q02223
• storage temp.: −20°C
• Gene Information: human ... TNFRSF17(608)

Description

Biochem/physiol Actions

BCMA, a member of the TNF receptor superfamily, binds to the TNF ligands, APRIL and BAFF. It stimulates the production of IgM in peripheral blood B cells and increases survival of cultured B cells.

Member of the TNF receptor superfamily; binds to the TNF ligands, APRIL and BAFF; stimulates the production of IgM in peripheral blood B cells and increases survival of cultured B cells.

The extracellular domain (amino acids 1-54) of human BCMA is fused to the Fc portion of human IgG.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated mouse B cells.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)