AV53669
Anti-FGFR1OP (AB1) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-FGFR1 oncogene partner, Anti-FOP
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
41 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FGFR1OP(11116)
General description
FGFR1 oncogene partner is a protein encoded by the FGFR1OP gene in humans. The fibroblast growth factor receptor 1 (FGFR1) oncogene partner called FOP is a centrosomal protein that is involved in the anchoring of microtubules (MTS) to subcellular structures.
Immunogen
Synthetic peptide directed towards the N terminal region of human FGFR1OP
application
Anti-FGFR1OP (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
Biochem/physiol Actions
FGFR1OP (FGFR1 oncogene partner)/FOP encodes a hydrophilic centrosomal protein predominantly expressd in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis and pancreas. It interacts with EB1 and facilitates the microtubules anchoring to the centrosomes. It plays an important role in normal proliferation and differentiation of the erythroid lineage. Attenuation of Fgfr1 disrupts cochlear hair cell formation.
Sequence
Synthetic peptide located within the following region: FLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLE
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.
Xiumin Yan et al.
Molecular biology of the cell, 17(2), 634-644 (2005-11-30)
The anchoring of microtubules (MTs) to subcellular structures is critical for cell shape, polarity, and motility. In mammalian cells, the centrosome is a prominent MT anchoring structure. A number of proteins, including ninein, p150Glued, and EB1, have been implicated in
G Guasch et al.
Molecular and cellular biology, 21(23), 8129-8142 (2001-11-02)
The FOP-fibroblast growth factor receptor 1 (FGFR1) fusion protein is expressed as a consequence of a t(6;8) (q27;p12) translocation associated with a stem cell myeloproliferative disorder with lymphoma, myeloid hyperplasia and eosinophilia. In the present report, we show that the
C Popovici et al.
Blood, 93(4), 1381-1389 (1999-02-09)
In patients with an atypical stem-cell myeloproliferative disorder with lymphoma (B or T cell), myeloid hyperplasia, and eosinophilia, the chromosome 8p11-12 region is the site of a recurrent breakpoint that can be associated with three different partners, 6q27, 9q32-34, and
Aleksandra Mikolajka et al.
Journal of molecular biology, 359(4), 863-875 (2006-05-13)
The fibroblast growth factor receptor 1 (FGFR1) oncogene partner, FOP, is a centrosomal protein that is involved in the anchoring of microtubules (MTS) to subcellular structures. The protein was originally discovered as a fusion partner with FGFR1 in oncoproteins that
Kazuya Ono et al.
PLoS genetics, 10(1), e1004118-e1004118 (2014-01-28)
Inner ear mechanosensory hair cells transduce sound and balance information. Auditory hair cells emerge from a Sox2-positive sensory patch in the inner ear epithelium, which is progressively restricted during development. This restriction depends on the action of signaling molecules. Fibroblast
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