Skip to Content
MilliporeSigma
All Photos(2)

Key Documents

AV45623

Sigma-Aldrich

Anti-NR1I3 (AB4) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-CAR, Anti-CAR1, Anti-MB67, Anti-MGC150433, Anti-MGC97144, Anti-MGC97209, Anti-Nuclear receptor subfamily 1, group I, member 3

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

MDL number:
MFCD00802755
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

39 kDa

species reactivity

human, pig

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001070937

UniProt accession no.

Q5VTW5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR1I3(9970)

Immunogen

Synthetic peptide directed towards the N terminal region of human NR1I3

Application

Anti-NR1I3 (AB4) antibody produced in rabbit is suitable for western blotting at a concentration of 1.25μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.

Biochem/physiol Actions

Nuclear receptor subfamily 1, group I, member 3 (NR1I3), also known as constitutive androstane receptor (CAR; CAR1) is a nuclear receptor that acts with retinoid X receptor to regulate xenobiotic and endobiotic metabolism. The ligands for this receptor include steroid hormones, drugs and bilirubin. On binding the ligands, NR1l3 translocates to the nucleus and regulates the transcription of genes involved in drug metabolism, energy homeostasis and cancer development.

Sequence

Synthetic peptide located within the following region: MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
QC13939

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hui Yang et al.
Protein & cell, 5(2), 113-123 (2014-01-30)
The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes. Different from prototypical nuclear receptors, CAR can be activated by
Robert X Xu et al.
Molecular cell, 16(6), 919-928 (2004-12-22)
The X-ray crystal structure of the human constitutive androstane receptor (CAR, NR1I3)/retinoid X receptor alpha (RXRalpha, NR2B1) heterodimer sheds light on the mechanism of ligand-independent activation of transcription by nuclear receptors. CAR contains a single-turn Helix X that restricts the

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service