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Key Documents

AV44294

Sigma-Aldrich

Anti-UGT1A1 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-GNT1, Anti-HUG-BR1, Anti-UDP glucuronosyltransferase 1 family, polypeptide A1, Anti-UDPGT, Anti-UGT1, Anti-UGT1A

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

57 kDa

species reactivity

canine, mouse, rat, rabbit, horse, sheep, human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_000454

UniProt accession no.

P22309

Storage temp.

−20°C

Gene Information

human ... UGT1A1(54658)

Immunogen

The immunogen for anti-UGT1A1 antibody: synthetic peptide derected towards the middle region of human UGT1A1

Application

Anti-PSEN2 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.

Biochem/physiol Actions

UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1; GNT1) is an enzyme that catalyzes the transformation of small lipophilic molecules to water-soluble excretable metabolites via the glucuronidation pathway. Deficiency in UGT1A1 results in Crigler-Najjar syndrome and neonatal hyperbilirubinemia.

Sequence

Synthetic peptide located within the following region: ASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC14222

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D Yildiz et al.
Genetic counseling (Geneva, Switzerland), 24(3), 273-277 (2013-12-18)
Crigler-Najjar syndrome (CNS), caused by deficiency of bilirubin uridine diphosphate glucuronosyltransferase (UGT) 1A1, is a rare and autosomal recessive inherited disorder characterized by severe unconjugated nonhemolytic hyperbilirubinemia since birth. We present a girl with CNS type I caused by a
Sariya Prachukthum et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 95 Suppl 1, S13-S17 (2012-01-01)
Neonatal hyperbilirubinemia is a common problem in neonates and affects 60% of Asian newborn babies which is twice that found in Caucasians. These findings suggest that a genetic factor might be involved. Recently, a relationship between polymorphisms of the bilirubin
Junko Sugatani
Drug metabolism and pharmacokinetics, 28(2), 83-92 (2012-10-24)
Human UDP-glucuronosyltransferase (UGT) 1A1 is the enzyme that detoxifies neurotoxic bilirubin by conjugating it with glucuronic acid. UGT1A1 also plays a critical role in the detoxification and excretion of endogenous and exogenous lipophilic compounds mainly in the liver and gastrointestinal

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