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Key Documents

AV40847

Sigma-Aldrich

Anti-LARP7 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZP564K112, Anti-HDCMA18P, Anti-La ribonucleoprotein domain family, member 7, Anti-MGC104360

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

67 kDa

species reactivity

guinea pig, bovine, rabbit, horse, mouse, rat, canine, human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_056269

UniProt accession no.

Q4G0J3

storage temp.

−20°C

Gene Information

human ... LARP7(51574)

General description

La ribonucleoprotein domain family, member 7 (LARP7), a 7SK binding protein, is involved in small nuclear ribonucleoprotein (snRNP) 7SK-mediated regulation of transcription. LARP7 is a negative transcriptional regulator of polymerase II genes by mechanisms that involves the 7SK-RNP system. Down regulation of LARP7 may promote gastric tumorigenesis via p-TEFb dysregulation.

Specificity

Anti-LARP7 polyclonal antibody reacts with chicken, human, mouse, rat, bovine, and canine La ribonucleoprotein domain family, member 7 proteins.

Immunogen

The immunogen for anti-LARP7 antibody: synthetic peptide derected towards the C terminal of human LARP7

Application

Anti-LARP7 polyclonal antibody is used to tag La ribonucleoprotein domain family, member 7 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of La ribonucleoprotein domain family, member 7 in 7SK-RNP (ribonucleoprotein) system regulation of transcription

Sequence

Synthetic peptide located within the following region: WQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC21566

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Iván D'Orso et al.
Molecular and cellular biology, 32(23), 4780-4793 (2012-09-26)
Transcription factors regulate eukaryotic RNA polymerase II (Pol II) activity by assembling and remodeling complexes at multiple steps in the transcription cycle. In HIV, we previously proposed a two-step model where the viral Tat protein first preassembles at the promoter

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