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Key Documents

AV34629

Sigma-Aldrich

Anti-LAS1L antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLJ12525, Anti-LAS1-like (S. cerevisiae), Anti-dJ475B7.2

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

83 kDa

species reactivity

human, bovine, horse

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_112483

UniProt accession no.

Q9Y4W2

storage temp.

−20°C

Gene Information

human ... LAS1L(81887)

General description

Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. I has a molecular weight of 83 kDa.

Immunogen

The immunogen for anti-LAS1L antibody: synthetic peptide derected towards the middle region of human LAS1L

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

Sequence

Synthetic peptide located within the following region: SSFGSEAKAQQQEEQGSVNDVKEEEKEEKEVLPDQVEEEEENDDQEEEEE

Physical form

Lyophilized from PBS buffer with 2% sucrose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC8279

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Christopher D Castle et al.
Molecular and cellular biology, 30(18), 4404-4414 (2010-07-22)
Ribosome biogenesis is a highly regulated process ensuring that cell growth (increase in biomass) is coordinated with cell proliferation. The formation of eukaryotic ribosomes is a multistep process initiated by the transcription and processing of rRNA in the nucleolus. Concomitant
Han Liao et al.
Molecular biology of the cell, 32(20), ar3-ar3 (2021-07-29)
Accumulating evidence indicates that increased ribosome biogenesis is a hallmark of cancer. It is well established that inhibition of any steps of ribosome biogenesis induces nucleolar stress characterized by p53 activation and subsequent cell cycle arrest and/or cell death. However

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