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Key Documents

AV34483

Sigma-Aldrich

Anti-EGLN2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Egl nine homolog 2 (C. elegans)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

44 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_444274

UniProt accession no.

Q96KS0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EGLN2(112398)

General description

EGLN2 (PHD1) is a prolyl hydroxylase that regulates the degradation of alpha subunit of HIF-1. Furthermore, PHD1 expression is modulated by ARNT during hypoxic conditions. Studies in mice have revealed that EGLN2 can block cancer growth.
Rabbit Anti-EGLN2 antibody recognizes canine, human, mouse, and rat EGLN2.

Immunogen

Synthetic peptide directed towards the N terminal region of human EGLN2

Application

Rabbit Anti-EGLN2 antibody can be used for western blot applications at a concentration of 0.5 μg/ml.

Biochem/physiol Actions

The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. EGLN2 encodes an enzyme responsible for this posttranslational modification. Alternative splicing of EGLN2 results in three transcript variants encoding different isoforms.

Sequence

Synthetic peptide located within the following region: SAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRL

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC3813

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Neta Erez et al.
Cancer research, 63(24), 8777-8783 (2003-12-26)
Hypoxic stress is one of the major selective pressures in the microenvironment of solid tumors, and overcoming this restriction is essential for tumor progression. One of the key factors driving the cellular response to lack of oxygen is hypoxia inducible
Neta Erez et al.
FEBS letters, 567(2-3), 311-315 (2004-06-05)
The recent identification of hypoxia-inducible-factor (HIF) prolyl hydroxylases (PHD1, 2, and 3), which modify HIF-1 alpha in an oxygen-dependent manner, provided an important link between oxygen availability and hypoxia-induced gene expression. However, little is known about the regulation of the

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