BRD2 encodes a transcription factor that is a bromodomain containing protein. Brd2/RING3 is known to associate with the chromatin binding domain of LANA-1 in KSHV (Kaposi′s sarcoma-associated herpesvirus)-infected cells. BRD2 may also be a susceptibility gene for juvenile myoclonic epilepsy. Rabbit Anti-BRD2 (AB2) antibody recognizes human, mouse, rat, canine, zebrafish, chicken, bovine, and pig BRD2.
Immunogen
Synthetic peptide directed towards the middle region of human BRD2
Application
Rabbit Anti-BRD2 is suitable for western blot applications at a concentration of 0.5 μg/ml.
Biochem/physiol Actions
BRD2 encodes a mitogen-activated kinase which localizes to the nucleus. BRD2 maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.
Sequence
Synthetic peptide located within the following region: QEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDD
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Journal of virology, 79(21), 13618-13629 (2005-10-18)
Latency-associated nuclear antigen 1 (LANA-1) of Kaposi's sarcoma-associated herpesvirus (KSHV) mediates the episomal replication of the KSHV genome, as well as transcriptional regulation, in latently infected cells. Interaction of LANA-1 with cellular chromatin is required for both these functions. An
American journal of human genetics, 73(2), 261-270 (2003-06-28)
Juvenile myoclonic epilepsy (JME) is a common form of generalized epilepsy that starts in adolescence. A major JME susceptibility locus (EJM1) was mapped to chromosomal region 6p21 in three independent linkage studies, and association was reported between JME and a
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