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Key Documents

AV32669

Sigma-Aldrich

Anti-IRF4 antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Interferon Regulatory factor 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

52 kDa

species reactivity

mouse, rat, guinea pig, horse, dog, rabbit, human, bovine

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_002451

UniProt accession no.

Q15306

shipped in

wet ice

Storage temp.

−20°C

Gene Information

human ... IRF4(3662)

General description

IRF4 is a transcription factor that is expressed primarily in the lymphocytes. Studies in mice have shown that IRF4 deficiencies can cause lymphadenopathy. IRF4 defects can also lead to impaired cytotoxic and anti-cancer responses.
Rabbit Anti-IRF4 antibody recognizes bovine, pig, zebrafish, chicken, canine, human, mouse, and rat IRF4.

Immunogen

Synthetic peptide directed towards the N terminal region of human IRF4

Application

Rabbit Anti-IRF4 antibody can be used for western blot applications at a concentration of 5μg/ml.

Biochem/physiol Actions

IFN regulatory factor (IRF)-4 is a lymphoid/myeloid-restricted member of the IRF transcription factor family that plays an essential role in the homeostasis and function of mature lymphocytes. IRF-4 expression is tightly regulated in resting primary T cells and is transiently induced at the mRNA and protein levels after activation by Ag-mimetic stimuli such as TCR cross-linking or treatment with phorbol ester and calcium ionophore (PMA/ionomycin).

Sequence

Synthetic peptide located within the following region: LDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQ

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC2097

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H W Mittrücker et al.
Science (New York, N.Y.), 275(5299), 540-543 (1997-01-24)
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy.

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