CIC, a human homolog of Drosophila capicua, encodes a high mobility group box (HMG-box) transcription factor that is key sensor of receptor tyrosine kinase (RTK) signaling in Drosophila and mammals. CIC functions as a repressor of RTK-responsive genes, keeping them silent in the absence of signaling. CIC is susceptible to fusion to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation, wherein the fusion product upregulates PEA3 family genes in Ewing-like sarcomas. Mutations in CIC are believed to contribute human oligodendroglioma.
Rabbit polyclonal anti-CIC reacts with human, mouse, rat, bovine, and canine capicua homolog (Drosophila) proteins.
Immunogen
The immunogen for anti-CIC antibody: synthetic peptide derected towards the N terminal of human CIC
Application
Rabbit Anti-CIC antibody can be used for IHC (4-8μg/ml, using paraffin-embedded tissues) and western blot (1.25μg/ml) applications.
Rabbit polyclonal anti-CIC is used to tag capicua homolog (Drosophila) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of capicua homolog (Drosophila) in the regulation of RTK-promoted gene expression and various cancers such as Ewing-like sarcomas and oligodendrogliomas.
Sequence
Synthetic peptide located within the following region: PSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPE
Physical form
Lyophilized from PBS buffer with 2% sucrose
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
CIC gene is frequently mutated in oligodendroglial tumors with 1p19q codeletion. However, clinical and biological impact remain poorly understood. We sequenced the CIC gene on 127 oligodendroglial tumors (109 with the 1p19q codeletion) and analyzed patients' outcome. We compared magnetic
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