Rabbit polyclonal anti-SMAD7 antibody reacts with human, mouse, rat, and canine SMAD family member 7 proteins.
SMADs are intracellular signaling molecules that activate TGFβ genes in response to ligand induced activation of TGFβ receptors. SMAD family member 7 (SMAD7) is a TGF-β pathway inhibitor that blocks activation of R-SMADs and Co-SMADs.
Immunogen
The immunogen for anti-SMAD7 antibody: synthetic peptide derected towards the N terminal of human SMAD7
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper)
Rabbit Anti-SMAD7 antibody can be used for western blot applications at a concentration of 1.0μg/ml.
Rabbit polyclonal anti-SMAD7 antibody is used to tag SMAD family member 7 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of SMAD family member 7 in transforming growth factor-β (TGF-β) cell signaling.
Sequence
Synthetic peptide located within the following region: EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHH
Physical form
Lyophilized from PBS buffer with 2% sucrose
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Keratoconus (KC) is a corneal thinning disease of unknown etiology whose pathophysiology is correlated with the presence of a thin corneal stroma and altered extracellular matrix (ECM). Transforming growth factor-β (TGF-β) signaling is a key regulator of ECM secretion and
The Journal of biological chemistry, 292(47), 19423-19440 (2017-10-07)
The widely used carbamate pesticide carbofuran causes neurophysiological and neurobehavioral deficits in rodents and humans and therefore poses serious health hazards around the world. Previously, we reported that gestational carbofuran exposure has detrimental effects on hippocampal neurogenesis, the generation of
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
