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Key Documents

AV31974

Sigma-Aldrich

Anti-CHX10 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CHX10, Anti-HOX10, Anti-MCOP2, Anti-MCOPCB3, Anti-RET1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

39 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_878314

UniProt accession no.

P58304

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHX10(338917)

General description

CHX10 is a retinal homeo domain-containing protein. Mutations in CHX10 have been liked to human microphthalmia/anophthalmia.
Rabbit Anti-CHX10 antibody recognizes human, mouse, and canine CHX10.

Immunogen

Synthetic peptide directed towards the C terminal region of human CHX10

Application

Rabbit Anti-CHX10 antibody can be used for western blot applications at a concentration of 0.5μg/ml.

Biochem/physiol Actions

Human CHX10 is expressed in progenitor cells of the developing neuroretina and in the inner nuclear layer of the mature retina. The strong conservation in vertebrates of the CHX10 sequence, pattern of expression and loss-of-function phenotypes demonstrates the evolutionary importance of the genetic network through which this gene regulates eye development.

Sequence

Synthetic peptide located within the following region: ESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKM

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC4832

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Zihan Zhang et al.
The EMBO journal, 40(19), e107974-e107974 (2021-08-31)
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E Ferda Percin et al.
Nature genetics, 25(4), 397-401 (2000-08-10)
Isolated human microphthalmia/anophthalmia, a cause of congenital blindness, is a clinically and genetically heterogeneous developmental disorder characterized by a small eye and other ocular abnormalities. Three microphthalmia/anophthalmia loci have been identified, and two others have been inferred by the co-segregation
Zhemin Shi et al.
The FEBS journal, 284(7), 1096-1109 (2017-03-16)
The aberrant accumulation of β-amyloid peptide (Aβ) in the brain is a key feature of Alzheimer's disease (AD), and enhanced cleavage of β-amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) has a major causative role in AD. Despite

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