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Key Documents

AV02017

Sigma-Aldrich

Anti-BRCA1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Breast cancer 1, early onset

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

mol wt

76 kDa

species reactivity

human

packaging

pkg of 100 μL buffered aqueous solution
pkg of 50 μg lyophilized powder

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_009235

UniProt accession no.

P38398

storage temp.

−20°C

Gene Information

human ... BRCA1(672)

General description

BRCA1 has been identified as the susceptibility gene for breast and ovarian cancers. The protein encoded by this gene regulates normal embryonic growth. BRCA1 has also been implicated in prostate cancer.
Rabbit Anti-BRCA1 antibody binds to human, rat, and canine BRCA1.

Immunogen

The immunogen for anti-BRCA1 antibody: synthetic peptide derected towards the N terminal of human BRCA1

Application

Rabbit Anti-BRCA1 antibody can be used for western blot (0.5μg/ml) and immunohistochemical (4-8μg/ml, using paraffin-embedded tissues) applications.

Sequence

Synthetic peptide located within the following region: MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLK

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC0144

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E M Rosen et al.
Cancer investigation, 19(4), 396-412 (2001-06-19)
The breast cancer susceptibility gene BRCA1 on chromosome 17q21 encodes an 1863 amino acid protein that is important for normal embryonic development. Germline mutations of this gene are linked to a significantly increased lifetime risk for breast and/or ovarian cancer
Y Miki et al.
Science (New York, N.Y.), 266(5182), 66-71 (1994-10-07)
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles.

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