Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that is involved in Wnt and PI3K signaling. GSK3A has been implicated in memory dysfunctions and neurodegeneration related to Alzheimer′s disease. Rabbit Anti-GSK3A antibody recognizes bovine, human, mouse, and ratGSK3A.
Immunogen
Synthetic peptide directed towards the N terminal region of human GSK3A
Application
Rabbit Anti-GSK3A antibody is suitable for use in western blot applications at 1.25μg/ml.
Sequence
Synthetic peptide located within the following region: MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGK
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Abnormalities in molecular signalling have been implicated in neurodegeneration. It is emerging that glycogen synthase kinase-3 (GSK-3) is a key signalling molecule that induces neurodegeneration and deficits in memory formation related to Alzheimer's disease (AD). Early stages of AD are
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