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Key Documents

A9900

Sigma-Aldrich

[Sar1, Thr8]-Angiotensin II acetate salt hydrate

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C44H69N13O11 · xC2H4O2 · yH2O
Molecular Weight:
956.10 (anhydrous free base basis)
MDL number:
MFCD00133979
UNSPSC Code:
12352200
NACRES:
NA.32

Quality Level

200

assay

≥97% (HPLC)

form

solid

storage temp.

−20°C

Gene Information

human ... AGTR1(185) , AGTR2(186) , AGTRAP(57085)
mouse ... AGTR1(11607) , AGTR1B(11608) , AGTR2(11609) , AGTRAP(11610)
rat ... AGTR1(24180) , AGTR1B(81638) , AGTR2(24182) , AGTRAP(298646)

Amino Acid Sequence

Sar-Arg-Val-Tyr-Ile-His-Pro-Thr

Biochem/physiol Actions

Potent, long-acting antagonist of angiotensin II.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
109K5053
103K51244
103K51243
103K51242
103K51241

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R K Tuominen et al.
Journal of neurochemistry, 56(4), 1292-1298 (1991-04-01)
Previous studies from our laboratory suggest that protein kinase C (PKC) is involved in the angiotensin II (AII)-induced increase in the expression of genes encoding proenkephalin and catecholamine biosynthesizing enzymes in primary cultured bovine adrenal medullary (BAM) cells. The purpose
S Ito et al.
The American journal of physiology, 270(6 Pt 2), R1317-R1323 (1996-06-01)
The rostral ventrolateral medulla (RVLM) plays a primary role in the tonic and phasic control of arterial blood pressure. Stimulation of angiotensin receptors in this region appears to contribute to the tonic excitatory drive of RVLM neurons involved in the
Y H Ku et al.
Peptides, 20(2), 171-176 (1999-07-28)
In urethane-anesthetized rats, microinjection of angiotensin II (AII) into either the subfornical organ (SFO), nucleus paraventricularis (NPV), or rostral ventrolateral medulla (RVL), respectively, all induced pressor responses, but the heart rate remained unchanged. Preinjection of [Sar1, Thr8]-angiotensin II (ST-AII, an

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