A9376

Adenosine 2′:3′-cyclic monophosphate sodium salt

≥93%

• Synonym(s): 2′,3′-cAMP sodium salt
• Linear Formula: C₁₀H₁₁N₅O₆PNa
• CAS Number: 37063-35-7
• Molecular Weight: 351.19
• EC Number: 253-328-3
• MDL number: MFCD00005757
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891439
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥93%
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H]4OP([O-])(=O)O[C@@H]34
• InChI: 1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7-6(4(1-16)19-10)20-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
• InChI key: VSDSIACSNXHGOV-MCDZGGTQSA-M

Description

Application

Adenosine 2′:3′-cyclic monophosphate sodium salt has been used in lysis buffer for affinity purification and also in microscale thermophoresis measurements.[1] It has also been used in electrophysiological studies of Tenebrio tubules.[2]

Biochem/physiol Actions

Adenosine 2′,3′-cyclic monophosphate (2′,3′-cAMP) is believed to serve as an extracellular source of adenosine. The release of extracellular 2′,3′-cAMP occurs in response to injury. 2′,3′-cAMP may be used to study the distribution and specificity of its degrading enzymes in the context of unique biological activities. 2′,3′-cAMP may also be used to study apoptosis induced at the level of mitochondrial permeability transition pores. 2′,3′-cAMP is converted into 2′-AMP and 3′-AMP which inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors.

Caution

Caution: Do not confuse with the common adenosine 2′(3′)-monophosphate (mixed isomers).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable