A9354
Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH trifluoroacetate salt
≥95% (HPLC), powder
Synonym(s):
Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
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About This Item
Empirical Formula (Hill Notation):
C100H144N30O20S · xC2HF3O2
Molecular Weight:
2118.47 (free base basis)
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
protect from light
under inert gas
color
red to purple
shipped in
wet ice
storage temp.
−20°C
Amino Acid Sequence
Ac-Arg-Glu-EDANS-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys-DABCYL-Arg
Biochem/physiol Actions
α-Secretase substrate II, fluorogenic.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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H Komano et al.
The Journal of biological chemistry, 273(48), 31648-31651 (1998-11-21)
Human beta-amyloid precursor protein (APP) introduced into yeast undergoes alpha-secretase-type cleavage, suggesting that yeast have alpha-secretase-like protease(s). Here we report that two structurally and functionally related glycosyl-phosphatidylinositol-linked yeast aspartyl proteases, Mkc7p and Yap3p (collectively termed yapsin), are responsible for alpha-secretase-type
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