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A8104

Sigma-Aldrich

Anti-Ataxin-7 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~96 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL using transfected COS-1 cells

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATXN7(6314)
mouse ... Atxn7(246103)

General description

Ataxin-7 is a protein encoded by the spinocerebellar ataxia type 7 (SCA7) gene. Ataxin-7 is known to affect cone-rod homeobox protein (CRX) functions that eventually cause cone-rod dystrophy in mouse models of SCA7.
Rabbit Anti-Ataxin-7 antibody recognizes human Ataxin-7.

Immunogen

synthetic peptide corresponding to amino acid residues 1-17 from human ataxin-7. This sequence is completely conserved in mouse ataxin-7.

Application

Rabbit Anti-Ataxin-7 antibody can be used for western blot assays at 1μg/ml.

Physical form

Solution in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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A R La Spada et al.
Neuron, 31(6), 913-927 (2001-10-03)
Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a CAG repeat expansion. To determine the mechanism of neurotoxicity, we produced transgenic mice and observed a cone-rod dystrophy. Nuclear inclusions were present, suggesting that the disease pathway

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