A6604

A-350619 hydrochloride

≥98% (HPLC), solid

• Synonym(s): 3-[2-(4-Chlorophenylthio)phenyl]-N-(4-dimethylaminobutyl)acrylamide
• Empirical Formula (Hill Notation): C₂₁H₂₅ClN₂OS · HCl
• CAS Number: 538368-27-3
• Molecular Weight: 425.41
• MDL number: MFCD06798332
• UNSPSC Code: 41106305
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: solid
• color: white
• mp: 175.2-176.7 °C
• solubility: H₂O: 23 mg/mL
• originator: Abbott
• storage temp.: 2-8°C

Description

General description

Guanylyl cyclases are signal transduction enzyme that convert GTP to cyclic GMP. Soluble guanylate cyclase is activated by a gaseous ligand, nitric oxide.. The nitric oxide activation of soluble guanylate, resulting in GTP conversion to GMP, is important in physiological processes such as as smooth muscle relaxation, neurotransmission, inhibition of platelet aggregation and immune response. A-350619 is an activator of soluble guanylyl cyclase.

Application

A-350619 relaxes cavernosum tissue strips in a dose dependent manner with EC₅₀ of 80 μMM. Because A-350619 at 1 μMmol/kg induces penile erection in a conscious rat model, it may be useful as an alternate method of enhancing the effect of nitric oxide for the treatment of sexual dysfunction.

Biochem/physiol Actions

A-350619 modulates catalytic properties of soluble guanylyl cyclase; it increases V_mas from 0.1 to 14.5 μmol/min/mg and lowers K_m from 300 to 50 μM. A-350619 activation of soluble guanylate cyclase depends on the presence of a heme moiety in the enzyme and synergy with nitric oxide.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under license from Abbott Laboratories

Safety Information

• pictograms: GHS05,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H315,H318,H335,H410
• pcodes: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves