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A5719

Sigma-Aldrich

Anti-FITC-Alkaline Phosphatase antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

conjugate

alkaline phosphatase conjugate

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

technique(s)

dot blot: 1:2,000 using fluoresceinated nucleic acid probes

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

General description

FITC (fluorescein isothiocyanate) is a fluorophore that absorbs ultraviolet or blue light and emits visible yellow-green light. Fluorescent labeling allows quick and precise localization of antigen-antibody associations in tissues and cells. FITC is a widely used antibody marker in immunofluorescence assays, as protein-FITC conjugation is comparatively a simple task and usually does not interfere with protein function. FITC is also utilized as a hapten to label proteins. Thus, anti-FITC antibodies can facilitate the analyses of FITC labeled proteins and antibody responses to haptens.

Immunogen

FITC conjugated to BSA

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Immunohistochemistry of paraffin embedded, 2% paraformaldhyde fixed adult rectal sections was performed using alkaline phosphatase-conjugated rabbit anti-FITC antibody (A4843) at a 1:100 dilution.
Rabbit Anti-FITC-Alkaline Phosphatase antibody has been used to detect CFSE labelled cells using immunohistochemical techniques. The antibody can also be used for dot blot (1:2,000 using fluorinated nucleic acid probes).
The conjugate is formulated to detect FITC-labeled, nucleic acid probes in membrane-based blotting applications.

Caution

Do not freeze.

Physical form

Solution in Tris-buffered saline, pH 8.0, containing 1% bovine serum albumin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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James B Chung et al.
International immunology, 14(2), 157-166 (2002-01-26)
Transitional immature B cells undergo apoptosis and fail to proliferate in response to BCR cross-linking, thus representing a target for negative selection of potentially autoreactive B cells in vivo. In agreement with recent reports, transitional B cells were divided into
Romana Illig et al.
RNA (New York, N.Y.), 15(8), 1588-1596 (2009-06-25)
During our study on HOXA13, HOXD12, and HOXD13 mRNA expression in human adult and embryonic tissues, we were confronted with the fact that, within our specimen collection, as in other University Departments in Europe, <20% of all samples yielded reliable
Sharon D Luikart et al.
BMC cell biology, 10, 60-60 (2009-09-01)
Monocytes, their progeny such as dendritic cells and osteoclasts and products including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha and IL-1beta play important roles in cancer, inflammation, immune response and atherosclerosis. We previously showed that mactinin, a degradative fragment of the
Cindy Gueguen et al.
PloS one, 9(2), e87367-e87367 (2014-03-04)
Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. In vitro oxidative stress activates poly(ADP-ribose)polymerase, decreases NAD(+) level, sirtuin 1 activity and finally leads to cell death. Poly(ADP-ribose)polymerase hyperactivation contributes to cell death. In addition, poly(ADP-ribose)polymerase inhibition restores NAD(+) level and

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