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A4976

Sigma-Aldrich

Anti-ADAMTS-4, C-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase with ThromboSpondin-4, Anti-Aggrecanase-1

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About This Item

MDL number:
MFCD03791405
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen 110 kDa (full-length)
antigen 40 kDa (minor band)

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:200-1:500

UniProt accession no.

O75173

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAMTS4(9507)

General description

ADAMTS-4 is a metalloproteinase member of the ADAM family of proteins that has disintegrin-like domains. ADAMTS-4 can be induced by LPS (lipopolysaccharide), IL-1, and retinoic acid and is known to cleave aggrecan, versican, and brevican. This metalloproteinase has been implicated in cartilage destruction, inflammation, arthritis and angiogenesis.
Rabbit Anti-ADAMTS-4, C-Terminal antibody can detect and localize human ADAMTS-4 (A Disintegrin And Metalloproteinase with ThromboSpondin-4 motif). By immunoblotting, the antibody recognizes a band of 110kDa, consistent with full-length ADAMTS-4. A minor band at 40kDa is also recognized.

Immunogen

synthetic peptide corresponding to C-terminal human ADAMTS-4.

Application

Rabbit Anti-ADAMTS-4, C-Terminal antibody can be used for western blot (1:200-1:500) assays.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
118K0935
087K1943
025K1129
082K1619

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J Kahn et al.
The American journal of pathology, 156(6), 1887-1900 (2000-06-15)
In the present study we have used a novel, comprehensive mRNA profiling technique (GeneCalling) for determining differential gene expression profiles of human endothelial cells undergoing differentiation into tubelike structures. One hundred fifteen cDNA fragments were identified and shown to represent
M D Tortorella et al.
Science (New York, N.Y.), 284(5420), 1664-1666 (1999-06-05)
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family
M D Tortorella et al.
The Journal of biological chemistry, 275(24), 18566-18573 (2000-04-07)
Aggrecan, the major proteoglycan of cartilage that provides its mechanical properties of compressibility and elasticity, is one of the first matrix components to undergo measurable loss in arthritic diseases. Two major sites of proteolytic cleavage have been identified within the

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