A4845
Monoclonal Anti-Alx-4 antibody produced in mouse
clone KABB4, purified immunoglobulin, buffered aqueous solution
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About This Item
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
KABB4, monoclonal
form
buffered aqueous solution
mol wt
antigen 41-43 kDa
species reactivity
human
technique(s)
western blot: 1-5 μg/mL
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ALX4(60529)
General description
Axl-4 is a homeodomain protein that is expressed on a variety of tissues including osteoblast precursors, dermal papilla of hair and whisker follicles, dental papilla of teeth, and mesenchymal cells. This protein functions as a transcriptional activator at epithelial-mesenchymal interfaces. Mouse Monoclonal Anti-Alx-4 antibody binds to human AXL-4.
Immunogen
recombinant full length Alx-4.
Application
Mouse Monoclonal Anti-Alx-4 antibody has been used for western blot analysis.
Physical form
Solution at approximately 1 mg/ml in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
Preparation Note
Purified using protein G.
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R Hudson et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 213(2), 159-169 (1998-10-24)
We have recently demonstrated that the retinoblastoma family of negative cell cycle regulators can form complexes with a class of developmental factors which contain paired-like (PL) homeodomains (Wiggan et al. [1998] Oncogene 16:227-236). Our screens led to the isolation of
S Qu et al.
Gene, 203(2), 217-223 (1998-01-13)
Homeodomain containing transcription factors serve important functions in patterning the embryo during vertebrate development. We have isolated cDNA clones encoding a novel protein, named Alx-4, that contains a paired-type homeodomain. Analysis of the homeodomain sequence shows that Alx-4 belongs to
Julie A Gaasch et al.
Gene, 369, 142-152 (2006-01-13)
Hepatocyte Growth Factor (HGF) and its protooncogene receptor c-Met regulate osteoclast function by activating pp60(c-Src) kinase and alpha(v)beta3 integrin. HGF causes transcription yet in osteoclast cells, this gene regulation is currently unknown. To begin characterization of HGF-regulated gene expression in
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