A4351

Anti-ADAM-17, Cytoplasmic Domain antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-A Disintegrin And Metalloproteinase-17, Anti-TACE, Anti-TNF-α Converting Enzyme
• MDL number: MFCD04040153
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen 110 kDa
• species reactivity: pig, rat, human
• concentration: ~1 mg/mL
• technique(s): western blot: 1:1,000
• UniProt accession no.: P78536
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ADAM17(6868) ; rat ... Adam17(57027)

Description

General description

ADAM-17 or tumor necrosis factor converting enzyme (TACE) is known to regulate several cellular functions such as cell growth and movement. It has a varied array of substrates that include adhesion molecules, growth factors and their receptors, as well as many cytokines. Thus, ADAM-17 abnormalities have been associated with various disorders such as renal fibrosis, Alzheimer′s disease, rheumatoid arthritis, cancer, diabetes and cardiac disorders.
Rabbit anti-ADAM-17, cytoplasmic domain antibody recognizes human, porcine, and rat ADAM17. It does not react with other ADAMs. By immunoblotting against the reduced protein, the antibody recognizes a band of 110kDa from conditioned media or cell lysates.

Immunogen

synthetic peptide corresponding to the cytoplasmic domain of full-length human ADAM-17.

Application

Rabbit anti-ADAM-17, cytoplasmic domain antibody can be used for western blot at a dilution of 1:1,000.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.