A4345
Anti-E1A (Adenovirus Early Region 1A) antibody produced in sheep
fractionated antiserum
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About This Item
biological source
sheep
conjugate
unconjugated
antibody form
fractionated antiserum
antibody product type
primary antibodies
clone
polyclonal
form
PBS solution
mol wt
antigen 43 kDa
species reactivity
viral
technique(s)
western blot: 10 μg/mL using whole extract of 293 cells
shipped in
dry ice
Storage temp.
−20°C
target post-translational modification
unmodified
General description
Adenovirus E1A gene modulates gene expression by associating with transcription factors in cells. Studies have reported that E1A regulates the stimulation of ICAM-1 through inflammatory signals in pulmonary epithelial cells. E1A has also been implicated in chronic obstructive pulmonary disease (COPD). Furthermore, E1A is known to mediate tumor suppression by rendering epithelial cells sensitive to anoikis. Sheep Anti-E1A (Adenovirus Early Region 1A) antibody binds to E1A using immunoblotting (43kDa).
Immunogen
GST-E1A fusion protein.
Application
Anti-E1A (Adenovirus Early Region 1A) antibody can be used at 10μg/mL for western blot assays using whole extract of 293 cells.
Physical form
Solution in phosphate buffered saline containing 0.08% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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S M Frisch
Mutation research, 350(1), 261-266 (1996-02-19)
Tumor suppressor genes such as Rb and p53 usually kill tumor cells when overexpressed ectopically. This is a consequence of their normal cell cycle regulatory functions. By contrast, the E1a gene of adenovirus, a common cold virus, converts tumor cells
N Keicho et al.
American journal of respiratory cell and molecular biology, 16(1), 23-30 (1997-01-01)
Previous studies from our laboratory demonstrated that adenovirus E1A DNA and proteins are detected in lungs of patients with chronic obstructive pulmonary disease (COPD). Since adenovirus E1A gene products are known to regulate the expression of many genes by interacting
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