A4226

Anti-ADAM-17, Propeptide Domain antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-A Disintegrin And Metalloproteinase-17, Anti-TACE, Anti-TNF-α Converting Enzyme
• MDL number: MFCD04040154
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• species reactivity: rat, pig, human
• concentration: ~1 mg/mL
• technique(s): western blot: 1:1,000
• UniProt accession no.: P78536
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... ADAM17(6868) ; rat ... Adam17(57027)

Description

General description

ADAM-17 or tumor necrosis factor converting enzyme (TACE) is known to regulate several cellular functions such as cell growth and movement. It has a varied array of substrates that include adhesion molecules, growth factors and their receptors, as well as many cytokines. Thus, ADAM-17 abnormalities have been associated with various disorders such as renal fibrosis, Alzheimer′s disease, rheumatoid arthritis, cancer, diabetes and cardiac disorders.
Rabbit anti-ADAM-17, propeptide domain antibody binds to human ADAM-17. The antibody reacts with human, porcine, and rat ADAM17 and does not react with other ADAMs. By immunoblotting against the reduced protein, the antibody recognizes a band of 110kDa from conditioned media or cell lysates.

Immunogen

synthetic peptide corresponding to the propeptide domain of human ADAM-17.

Application

Rabbit anti-ADAM-17, propeptide domain antibody can be used for western blotting (1:1,000) applications.

Physical form

Solution in 0.01 M phophate buffered saline containing 50% glycerol and 0.05% sodium azide.