immunocytochemistry: suitable western blot: 4-8 μg/mL using A431 cells extract
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Annexin I belongs to the annexin superfamily. It is associated with cellular membranes in the presence of Ca2+. The protein has a large conserved core domain (~30kDa) required for calcium and phospholipid association. This gene is widely expressed in tissues.
Immunogen
mixture of native membrane proteins from human bone tissues, which includes whole native annexin proteins.
Application
Monoclonal Anti-Annexin I antibody produced in mouse has been used in western blotting.
Biochem/physiol Actions
Annexin I is an anti-inflammatory factor and plays an important role in neuroprotection. It is associated with the removal of apoptotic cells, protects from ischemia-like injury and prevents hepatic inflammation. Annexin I also protects against the breakdown of blood-brain-barrier in Alzheimer′s disease. It is involved in the homeostasis of innate immune system by mediating immune cells (for instance, neutrophils and macrophages).
Physical form
Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Journal of immunology (Baltimore, Md. : 1950), 162(9), 5398-5406 (1999-05-05)
Despite being a major group of intracellular pathogens, the role of class I-restricted T cells in the clearance of Gram-negative bacteria is not resolved. Using a murine typhoid model, a role for class I-restricted T cells in the immune response
A fragmented form of annexin A1 is secreted from C2C12 myotubes by electric pulse-induced contraction.
Goto-Inoue N
Molecular and Cellular Biochemistry, 411, 173-173 (2016)
Annexin A1 Is a Key Modulator of Mesenchymal Stromal Cell-Mediated Improvements in Islet Function.
Rackham CL
Diabetes, 65, 129-129 (2016)
Annexin A1 restores A?1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway.
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