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assay
≥75% (HPLC)
form
powder
color
faintly beige
solubility
H2O: 10 mg/mL
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
Application
A40926 is an antibiotic that is an analog of teicoplanin and the precursor to dalbavanain. It is a mixture of related glycopeptides isolated from Nonomuraea sp. A40926 is used to study mechanisms of glycopeptide resistance [1], the activation of antibiotic production [2] and is used in pharmokinetic studies[3].
Biochem/physiol Actions
A40926 is effective against Gram positive bacteria, and was found to be highly bactericidal against Neisseria gonorrhoeae. The mechanism of action is via inhibition of bacterial cell wall formation.
A40926 is effective against Gram positive bacteria, and was found to be highly bactericidal against Neisseria gonorrhoeae.[4] The mechanism of action is via inhibition of bacterial cell wall formation. A40926 is a complex of four main factors. These factors contain a fatty acid as part of a glycolipid attached to the peptide backbone.
Other Notes
A40926 is an antibiotic that is an analog of teicoplanin and the precursor to dalbavanain. It is a mixture of related glycopeptides isolated from Nonomuraea sp.
Keep container tightly closed in a dry and well-ventilated place.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Giorgia Letizia Marcone et al.
Antimicrobial agents and chemotherapy, 54(6), 2465-2472 (2010-03-24)
In glycopeptide-resistant enterococci and staphylococci, high-level resistance is achieved by replacing the C-terminal d-alanyl-d-alanine of lipid II with d-alanyl-d-lactate, thus reducing glycopeptide affinity for cell wall targets. Reorganization of the cell wall in these organisms is directed by the vanHAX
B P Goldstein et al.
Antimicrobial agents and chemotherapy, 31(12), 1961-1966 (1987-12-01)
In the course of a search for glycopeptide antibiotics having novel biological properties, we isolated A40926. Produced by an actinomycete of the genus Actinomadura, A40926 is a complex of four main factors which contain a fatty acid as part of
Adelfia Talà et al.
Journal of bacteriology, 191(3), 805-814 (2008-12-03)
There is accumulating evidence that the ability of actinomycetes to produce antibiotics and other bioactive secondary metabolites has been underestimated due to the presence of cryptic gene clusters. The activation of dormant genes is therefore one of the most important
A Bernareggi et al.
Antimicrobial agents and chemotherapy, 32(2), 246-249 (1988-02-01)
A40926 is a new glycopeptide antibiotic with unique activity against Neisseria gonorrhoeae and high and prolonged levels in mouse blood (B. P. Goldstein, E. Selva, L. Gastaldo, M. Berti, R. Pallanza, F. Ripamonti, P. Ferrari, M. Denaro, V. Arioli, and
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