ADAM is a member of the disintegrin and metalloproteinase family of proteins which possess both adhesion and zinc protease functions. ADAM-10 is a sheddase with both a secreted and membrane-bound form. ADAM-10 null mice are embryonically lethal with neural and cardiac defects. Rabbit anti-ADAM-10 antibody can localize human ADAM 10 and does not detect other ADAMs.
Recognizes the furin cleavage site (58-60 kDa) of ADAM-10. Detects the latent form of the enzyme.
Immunogen
synthetic peptide corresponding to the prohormone convertase (PC) cleavage site of human ADAM-10.
Application
Rabbit anti-ADAM-10 antibody has been used for western blot assays.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
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