A2601
Anti-ADAM-12, Cytoplasmic Domain antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-A Disintegrin And Metalloproteinase-12, Anti-Meltrin-α
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ADAM12(8038)
General description
ADAM12 or Meltrin alpha is a protein that is involved in myoblast fusion which is similar to sperm-egg fusion aided by ADAMs 1 and 2. Two forms of ADAM12 have been described: ADAM12-S and ADAM12-L (short and long forms). The short form is a soluble, alternatively spliced form that lacks the trans membrane and cytoplasmic domains. The short form of ADAM12 has been reported to provoke myogenesis. ADAM12 is known to have regulation pathways via Src and Src tyrosine kinases.
Recognizes the full length, long form of ADAM-12 but not the soluble form of ADAM-12. Detects bands at 116 kDa (minor band), 92 kDa (major band), and cleaved products at 68 kDa and 40 kDa in reduced immunoblots.
The family of AMP deaminases enzymes catalyze the deamination of adenosine monophosphate to inosine monophosphate.
Immunogen
synthetic peptide corresponding to the cytoplasmic domain of human ADAM-12.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Enzyme-linked immunosorbent assay (1 paper)
Immunohistochemistry (1 paper)
Western Blotting (1 paper)
Rabbit anti-ADAM-12, cytoplasmic domain antibody has been used for ELISA applications. It can also be used for western blot assays (1:1,000).
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Jureerut Daduang et al.
Archives of medical science : AMS, 7(6), 1013-1016 (2012-02-14)
The "a distintegrin and metalloprotease" (ADAM) family contributes to regulation of the cell-cell and cell-matrix interaction that are critical determinants of malignancy. It also plays important roles in the degradation of the basement membrane during tumor invasion. To evaluate a
Jun Yu et al.
PloS one, 7(9), e43456-e43456 (2012-09-18)
Cancer associated stromal fibroblasts (CAFs) undergo transcriptional and phenotypic changes that contribute to tumor progression, but the mechanisms responsible for these changes are not well understood. Aberrant DNA methylation is an important cause of transcriptional alterations in cancer cells but
J M Bork et al.
The EMBO journal, 20(24), 7313-7322 (2001-12-18)
The Escherichia coli RecF, RecO and RecR pro teins have previously been implicated in bacterial recombinational DNA repair at DNA gaps. The RecOR-facilitated binding of RecA protein to single-stranded DNA (ssDNA) that is bound by single-stranded DNA-binding protein (SSB) is
Katarzyna Biadasiewicz et al.
Biology of reproduction, 90(5), 101-101 (2014-04-04)
ADAM12, consisting of a membrane-bound (ADAM12L) and a secreted (ADAM12S) form, is expressed exclusively in regenerating and developing tissue as well as in certain cancer types. Strong ADAM12 expression levels have been noticed in the human placenta, and deregulated ADAM12S
A Suzuki et al.
Oncogene, 19(51), 5842-5850 (2000-12-29)
Meltrin alpha/ADAM12 is a member of the ADAM/MDC family proteins characterized by the presence of metalloprotease and disintegrin domains. This protein also contains a single transmembrane domain and a relatively long cytoplasmic domain containing several proline-rich sequences. These sequences are
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
