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A228

Sigma-Aldrich

Nle-Antiflammin-2

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About This Item

Empirical Formula (Hill Notation):
C47H79N13O15
Molecular Weight:
1066.21
UNSPSC Code:
12352200
PubChem Substance ID:
329770778

form

solid

color

white

application(s)

cell analysis

storage temp.

−20°C

InChI

1S/C44H73N13O16/c1-6-7-10-25(50-41(69)29(16-33(60)61)52-36(64)24(46)14-23-18-48-20-49-23)37(65)53-28(15-32(47)59)40(68)51-26(11-8-9-12-45)38(66)57-35(22(4)5)43(71)55-27(13-21(2)3)39(67)54-30(17-34(62)63)42(70)56-31(19-58)44(72)73/h18,20-22,24-31,35,58H,6-17,19,45-46H2,1-5H3,(H2,47,59)(H,48,49)(H,50,69)(H,51,68)(H,52,64)(H,53,65)(H,54,67)(H,55,71)(H,56,70)(H,57,66)(H,60,61)(H,62,63)(H,72,73)/t24-,25+,26-,27-,28-,29-,30-,31-,35-/m0/s1

InChI key

QSFXTURAJLIZNL-IBFMKUTMSA-N

Application

Anti-inflammatory peptide; inhibits phospholipase A2 and the synthesis of platelet-activating factor.

Packaging

Product supplied in a sealed glass ampoule.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Robert Rauscher et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(4) (2021-01-21)
Epistasis refers to the dependence of a mutation on other mutation(s) and the genetic context in general. In the context of human disorders, epistasis complicates the spectrum of disease symptoms and has been proposed as a major contributor to variations
Ramlogan Sowamber et al.
Cancers, 12(5) (2020-05-01)
Epithelial ovarian cancer represents a group of heterogeneous diseases with high grade serous cancer (HGSC) representing the most common histotype. Molecular profiles of precancerous lesions found in the fallopian tube have implicated this tissue as the presumptive site of origin
C Tetta et al.
The Journal of pharmacology and experimental therapeutics, 257(2), 616-620 (1991-05-01)
Antiflammins are synthetic peptides corresponding to a region of similarity between uteroglobin and lipocortin I. These peptides inhibit synthesis of platelet-activating factor and release of arachidonic acid from neutrophils and macrophages stimulated by phagocytosis or tumor necrosis factor. Antiflammins containing
S Lloret et al.
Biochemical pharmacology, 44(7), 1437-1441 (1992-10-06)
The anti-inflammatory synthetic polypeptides referred to as antiflammins are thought to be inhibitors of phospholipase A2 (PLA2) (EC 3.1.1.4). These peptides are from the sequence of amino acids of greatest similarity between uteroglobin and lipocortin I. The effect of these
Elisa Molinari et al.
Scientific reports, 9(1), 10828-10828 (2019-07-28)
Joubert syndrome (JBTS) is an incurable multisystem ciliopathy syndrome. The most commonly mutated gene in JBTS patients with a cerebello-retinal-renal phenotype is CEP290 (alias JBTS5). The encoded CEP290 protein localises to the proximal end of the primary cilium, in the
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