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A2275

Sigma-Aldrich

[Sar1, Val5, Ala8]-Angiotensin II acetate salt hydrate

≥97% (HPLC), powder

Synonym(s):

Saralasin

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About This Item

Empirical Formula (Hill Notation):
C42H65N13O10 · xC2H4O2 · yH2O
CAS Number:
39698-78-7
Molecular Weight:
912.05 (anhydrous free base basis)
MDL number:
MFCD01939339
UNSPSC Code:
12352202
PubChem Substance ID:
24890641

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

O.CC(O)=O.CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(O)=O

InChI

1S/C42H65N13O10.C2H4O2.H2O/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65;1-2(3)4;/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47);1H3,(H,3,4);1H2/t24-,28-,29-,30-,31-,33-,34-;;/m0../s1

InChI key

YBZYNINTWCLDQA-UHKVWXOHSA-N

Gene Information

human ... AGTR1(185)
rat ... Agtr1(24180)

Amino Acid Sequence

Sar-Arg-Val-Tyr-Val-His-Pro-Ala

Biochem/physiol Actions

Competitive angiotensin II antagonist; inhibits pressor effects of angiotensin II in rats and lowers blood pressure in humans.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
089K5063
057K5102
084K51063
084K5106
069H5801

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S Matsubara et al.
Biological & pharmaceutical bulletin, 23(10), 1185-1188 (2000-10-21)
We have characterized angiotensin II (Ang II) receptor subtypes on rat submandibular gland membranes using a radioligand binding assay. [3H]Ang II binding to the membrane fractions exhibited both high (Kd =0.08 nm, Bmax =2.19 fmol/mg protein) and low (Kd =4.19
Koch Visser et al.
Endocrinology, 151(11), 5279-5293 (2010-10-01)
The liver plays an important role in inflammation and stress by producing the acute phase proteins (APPs) required for resolution of inflammation as well as by delivering systemic glucose, through gluconeogenesis, required to fuel the stress response. Disruption of the
L A de Arruda Camargo et al.
Regulatory peptides, 84(1-3), 91-96 (1999-10-27)
We determined the effects of losartan and CGP42112A (selective ligands of the AT1 and AT2 angiotensin receptors, respectively) and salarasin (a relatively nonselective angiotensin receptor antagonist) on urinary volume and urinary sodium and potassium excretion induced by administration of angiotensin
P B Timmermans et al.
Cardiologia (Rome, Italy), 39(12 Suppl 1), 397-400 (1994-12-01)
Angiotensin II (Ang II) is the primary mediator of the renin-angiotensin system (RAS). Inappropriate control of the RAS is critically involved in the development and maintenance of hypertension and congestive heart failure. The actions of Ang II are thought to
Renee C Gaspar et al.
Experimental neurology, 223(2), 394-400 (2009-09-12)
Amyloid plaque deposition in the brain is a hallmark of Alzheimer's disease, but recent evidence indicates that the disease may be primarily caused by soluble amyloid-beta (1-42) (Abeta) oligomers or Abeta-derived diffusible ligands (ADDLs). ADDLs induce cognitive deficits in animal

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