A2229
Anti-Apolipoprotein J antibody produced in goat
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Clusterin
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
western blot: 1:5,000-1:10,000
UniProt accession no.
shipped in
dry ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CLU(1191)
General description
Apolipoprotein J is a ubiquitously expressed glycoprotein that is involved in the differentiation and proliferation of cells. Apolipoprotein J in conjunction with apolipoprotein E may affect the onset of amyloid-beta deposition, and also may be involved in the local toxicity associated with these deposits. Hence, apolipoprotein J may function as a cerebrospinal fluid marker for Alzheimer′s disease.
Goat anti-apolipoprotein J antibody recognizes human apolipoprotein J and has negligible cross-reactivity with Type A-I, A-II, B, C-I, C-II, C-III and E apolipoproteins.
Goat anti-apolipoprotein J antibody recognizes human apolipoprotein J and has negligible cross-reactivity with Type A-I, A-II, B, C-I, C-II, C-III and E apolipoproteins.
Immunogen
Apolipoprotein Type J isolated from human plasma by density gradient centrifugation followed by HPLC purification.
Application
Goat anti-apolipoprotein J antibody can be used for immunohistochemistry applications using formalin-fixed, paraffin-embedded sections at a concentration ranging from 1:50-1:200. The antibody is also suitable for use in ELISA.
HEK293 cells were transfected with either an expression vector to over expression Clusterin or siRNA to knock down expression of Clusterin. Clusterin levels were monitored by western blot using goat anti-Clusterin antibody at 1:1000.
Physical form
Solution in 0.1 M sodium borate, 0.075 M sodium chloride, 0.005 M EDTA, pH 8.0, and 0.01% sodium azide as preservative.
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Warning
hcodes
Hazard Classifications
Repr. 2
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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David M Holtzman
Journal of molecular neuroscience : MN, 23(3), 247-254 (2004-06-08)
The epsilon4 allele of apolipoprotein E APOE is a risk factor for Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), and the epsilon2 allele is associated with a decreased risk for AD. There is strong evidence to suggest that a
Maja Puchades et al.
Brain research. Molecular brain research, 118(1-2), 140-146 (2003-10-16)
By comparing the cerebrospinal fluid (CSF) proteome between Alzheimer's disease (AD) patients and controls, it may be possible to identify proteins that play a role in the disease process and thus to study the pathogenesis of AD. Two-dimensional gel electrophoresis
Maurizio Scaltriti et al.
International journal of cancer, 108(1), 23-30 (2003-11-18)
Clusterin is overexpressed during tissue and cell involution and downregulated in proliferating cells. Its role in cell survival, cell death and neoplastic transformation remains debated. We studied the expression and distribution of clusterin mRNA and protein in human prostate carcinoma
Andrei Thomas-Tikhonenko et al.
Cancer research, 64(9), 3126-3136 (2004-05-06)
Effective treatment of malignant carcinomas requires identification of proteins regulating epithelial cell proliferation. To this end, we compared gene expression profiles in murine colonocytes and their c-Myc-transformed counterparts, which possess enhanced proliferative potential. A surprisingly short list of deregulated genes
Ioannis P Trougakos et al.
Cancer research, 64(5), 1834-1842 (2004-03-05)
Clusterin/Apolipoprotein J (CLU) is a heterodimeric ubiquitously expressed secreted glycoprotein that is implicated in several physiological processes and is differentially expressed in many severe physiological disturbances, including tumor formation and in vivo cancer progression. Despite extensive efforts, clarification of CLU's
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