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A1848

Sigma-Aldrich

Activated Leukocyte Cell Adhesion Molecule/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder

Synonym(s):

ALCAM, CD166, KG-CAM, MEMD, SC-1/DM-GRASP/BEN

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About This Item

MDL number:
MFCD03454280
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

human

recombinant

expressed in mouse NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

~120 kDa by SDS-PAGE (reducing)
calculated mol wt 83.5 kDa

impurities

endotoxin, tested

UniProt accession no.

Q13740

storage temp.

−20°C

Gene Information

human ... ALCAM(214)

Biochem/physiol Actions

Type I membrane glycoprotein. Member of the immunoglobulin supergene family.

Other Notes

Extracellular domain of human ALCAM (residues 1-526) fused to carboxy-terminal histidine-tagged Fc portion of human IgG1.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline.

Analysis Note

Measured by its ability to block adhesion of HUT-78, a human cutaneous T cell lymphoma, to immobilized recombinant human CD6/Fc protein.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLBG7915V
091K0319

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A Aruffo et al.
Immunology today, 18(10), 498-504 (1997-11-14)
The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and
Degen, W.G., et al.
The American Journal of Pathology, 152, 805-805 (1996)
M A Bowen et al.
The Journal of experimental medicine, 181(6), 2213-2220 (1995-06-01)
Antibody-blocking studies have demonstrated the role of CD6 in thymocyte-thymic epithelial (TE) cell adhesion. Here we report that CD6 expressed by COS cells mediates adhesion to TE cells and that this interaction is specifically blocked with an anti-CD6 monoclonal antibody

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