A1705
S-(5′-Adenosyl)-L-homocysteine Hydrolase from rabbit erythrocytes
buffered aqueous glycerol solution, ≥10 units/mg protein (Lowry)
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352200
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form
buffered aqueous glycerol solution
specific activity
≥10 units/mg protein (Lowry)
foreign activity
Adenosine deaminase activity ≤1%
shipped in
dry ice
storage temp.
−70°C
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Biochem/physiol Actions
Enzyme in vertebrates which catabolizes S-adenosyl-L-homocysteine.
Unit Definition
One unit will hydrolyze 1.0 nanomole of S-adenosyl-L-homocysteine to adenosine and L-homocysteine per min at pH 7.2 at 37 °C.
Physical form
Solution in 25 mM Tris, pH 7.4, containing 1 mM dithiothreitol, 1 mM EDTA, and 20% glycerol.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ajit Shokar et al.
Bioorganic & medicinal chemistry letters, 22(12), 4203-4205 (2012-05-15)
In the present study, we carried out a structure-activity analysis in Trichomonas vaginalis of a series of adenosine and uridine analogues. The most potent compounds were found to be 2' and 3' modified adenosine analogues some of which are potent
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Tomáš Honzík et al.
Molecular genetics and metabolism, 107(3), 611-613 (2012-09-11)
We report on the seventh known patient with S-adenosylhomocysteine hydrolase (SAHH) deficiency presenting at birth with features resembling phosphomannomutase 2 (PMM2-CDG Ia) deficiency. Plasma methionine and total homocysteine levels were normal at 2 months and increased only after the 8th
Laura Giusti et al.
Molecular bioSystems, 8(4), 1088-1099 (2012-02-02)
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M J Robins et al.
Journal of medicinal chemistry, 41(20), 3857-3864 (1998-09-28)
Treatment of a protected 9-(5, 6-dideoxy-beta-D-ribo-hex-5-ynofuranosyl)adenine derivative with silver nitrate and N-iodosuccinimide (NIS) and deprotection gave the 6'-iodo acetylenic nucleoside analogue 3c. Halogenation of 3-O-benzoyl-5,6-dideoxy-1, 2-O-isopropylidene-alpha-D-ribo-hex-5-enofuranose gave 6-halo acetylenic sugars that were converted to anomeric 1,2-di-O-acetyl derivatives and coupled with
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