Tranilast, N-(3,4-dimethoxycinnamoyl) anthranilic acid, suppresses collagen synthesis by various cells, including macrophages and fibroblasts, by interfering with the actions of transforming growth factor-beta 1. We investigated the effect of tranilast on progression of diabetic nephropathy (DN), since this process is
Structural modulation of Ant-Pro (anthranilic acid-proline) oligomers has been carried out by chirality alteration of the proline residues. The results suggest that the chirality altered oligomers show well-defined helical conformation featuring nine-membered hydrogen bonding interactions - without compromising conformational rigidity.
In this work, we report a competitive sensor performing "double recognition" for the specific capture of dopamine (DA) with the combination of boronic acid functional groups and molecularly imprinted cavities based on poly(aniline-co-anthranilic acid) (PANANA) as the support material. This
Journal of the American Chemical Society, 134(42), 17444-17447 (2012-10-04)
Members of the asperlicin family of fungal metabolites produced by Aspergillus alliaceus are known potent CCK(A) antagonists. Herein, we report the identification of the gene cluster responsible for directing their biosynthesis. We validate and probe the pathway by genetic manipulation
Research in recent years has considerably enhanced our understanding of the membrane-bound cytochrome P-450-catalyzed biotransformations in organisms. A remarkable similarity has become apparent between diversified animal groups with respect to the components and functional roles of the cytochrome P-450 systems.
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