Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 6.8, containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to compete with biotinylated recombinant human ANG-2 for binding to immobilized Tie-2/Fc in an ELISA.
Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, e.g., VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF-PDGFRs binding challenges this paradigm and calls for investigation of other ligand-receptor binding possibilities.
A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human
Proceedings of the National Academy of Sciences of the United States of America, 96(5), 1904-1909 (1999-03-03)
The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist
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