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A1354

Sigma-Aldrich

APRIL human

recombinant, expressed in NSO cells, >95% (SDS-PAGE), lyophilized powder

Synonym(s):

A Proliferation-inducing Ligand, TALL-2, TNFSF13, TRDL-1

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About This Item

MDL number:
MFCD03702795
UNSPSC Code:
12352200

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

23-25 kDa by SDS-PAGE (reducing)
calculated mol wt 18.6 kDa

impurities

endotoxin, tested

UniProt accession no.

O75888

storage temp.

−20°C

Gene Information

human ... TNFSF13(8741)

Physical form

Lyophilized from a 0.2 μm filtered solution in PBS and 0.5 M NaCl, containing 50 μg BSA per 1 μg cytokine

Analysis Note

The biological activity is measured by its ability to induce proliferation of anti-IgM-stimulated human B cells. Alternatively, the activity can be measured by its ability to bind immobilized rhBCMA/Fc.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Kelly et al.
Cancer research, 60(4), 1021-1027 (2000-03-08)
We have examined the activity of a new member of the tumor necrosis factor (TNF) family identified through Expressed Sequence Tag database searching using TNFalpha protein as the search query. We have termed this protein TNF-related death ligand-la (TRDL-1alpha). Traditional
P A Moore et al.
Science (New York, N.Y.), 285(5425), 260-263 (1999-07-10)
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS
J A Gross et al.
Nature, 404(6781), 995-999 (2000-05-09)
B cells are important in the development of autoimmune disorders by mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and co-stimulation of autoreactive T cells. zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor
P Schneider et al.
The Journal of experimental medicine, 189(11), 1747-1756 (1999-06-08)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF
M Hahne et al.
The Journal of experimental medicine, 188(6), 1185-1190 (1998-09-22)
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are
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