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A0976

Sigma-Aldrich

Monoclonal Anti-Angiostatin antibody produced in mouse

clone 79735, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-Angiostatin Kringle 1-3

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About This Item

MDL number:
MFCD03792411
UNSPSC Code:
12352203

biological source

mouse

recombinant

expressed in E. coli

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

79735, monoclonal

form

lyophilized powder

mol wt

antigen 38 kDa

species reactivity

human

should not react with

mouse

technique(s)

western blot: 1-2 μg/mL

isotype

IgG2a

UniProt accession no.

P00747

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PLG(5340)

General description

Angiostatin is an internal proteolytic fragment of plasminogen that has at least three kringle domains. This protein fragment functions as an endogenous angiogenesis inhibitor, and can also block endothelial cell proliferation,. Furthermore, angiostatin can specifically inhibit the growth of metastatic tumor.
Monoclonal Anti-Angiostatin recognizes human angiostatin. This antibody also recognizes plasminogen but shows no cross-reactivity with recombinant mouse angiostatin.

Immunogen

recombinant human angiostatin kringle 1-3 expressed in E. coli.

Application

Mouse monoclonal anti-angiostatin antibody can be used for western blot applications at 1-2 μg/mL.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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José Ángel Nicolás-Ávila et al.
STAR protocols, 2(1), 100286-100286 (2021-01-26)
Cardiac exophers are membrane-bound extracellular vesicles released by cardiomyocytes with varied content and an average diameter of 3.5 μm. Here, we provide a detailed protocol to enable the identification and purification of cardiomyocyte-derived exophers by using fluorescence-activated cell sorting for downstream
Z Wu et al.
Biochemical and biophysical research communications, 236(3), 651-654 (1997-07-30)
Angiostatin, a 38 kDa internal fragment of plasminogen, is an antiangiogenic endothelial cell inhibitor. It regresses several primary and metastatic tumors in mice. To produce recombinant angiostatin for further structural and functional studies, the mouse angiostatin gene preceded by a
M S O'Reilly et al.
Cell, 79(2), 315-328 (1994-10-21)
The phenomenon of inhibition of tumor growth by tumor mass has been repeatedly studied, but without elucidation of a satisfactory mechanism. In our animal model, a primary tumor inhibits its remote metastases. After tumor removal, metastases neovascularize and grow. When
Y Cao et al.
The Journal of biological chemistry, 271(46), 29461-29467 (1996-11-15)
Recently we have identified angiostatin, an endogenous angiogenesis inhibitor of 38 kDa which specifically blocks the growth of endothelial cells (O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C. , Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y.

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