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A0479

Sigma-Aldrich

Adrafinil

≥98% (HPLC), solid

Synonym(s):

2-[(Diphenylmethyl)sulfinyl]acetohydroxamic acid, CRL 40028, Olmifon

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About This Item

Empirical Formula (Hill Notation):
C15H15NO3S
CAS Number:
63547-13-7
Molecular Weight:
289.35
EC Number:
264-303-1
MDL number:
MFCD00865357
UNSPSC Code:
12352200
PubChem Substance ID:
24890429

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

DMSO: 35 mg/mL

SMILES string

ONC(=O)CS(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15,18H,11H2,(H,16,17)

InChI key

CGNMLOKEMNBUAI-UHFFFAOYSA-N

Biochem/physiol Actions

Agent promoting wakefulness; analog of Modafinil.

Caution

Hygroscopic

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
044K46211
044K4621

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A Delini-Stula et al.
Psychopharmacology, 101(1), 62-66 (1990-01-01)
Acute (10 or 20 mg/kg IP) and subchronic (2 x 5 or 10 mg/kg IP daily for 7 days) effects of desipramine, imipramine, maprotiline, (+)- and (-)-oxaprotiline enantiomers as well as selective 5-HT-uptake inhibitors citalopram and ifoxetine on yawning, induced
N W Milgram et al.
Pharmacology, biochemistry, and behavior, 66(2), 301-305 (2000-07-06)
Aged beagle dogs were trained on either a size or intensity discrimination task 2 h following treatment with either 20 mg/kg of adrafinil or a placebo control. Training continued until the dogs reached a predetermined criterion level of performance, or
M Hascoet et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 5(4), 481-489 (1995-12-01)
The binding and locomotor profile of a new sigma ligand, S14905, (isobutyl-N-(1-indan-2yl-piperid-4-yl)N-methyl carbamate, furamate) was studied. The binding data revealed that S14905 has a high affinity for sigma receptors and very low affinity for both dopamine D1 and D2 receptors.
R Nageswara Rao et al.
Biomedical chromatography : BMC, 23(8), 811-816 (2009-04-09)
A simple and rapid normal-phase HPLC method for enantiospecific separation of a psychostimulant, adrafinil (ADL), and its metabolite modafinil (MDL) in rat serum and urine was developed. The separation was accomplished on a normal-phase polysaccharide stationary phase Chiralcel OJ-H using
C Rozé et al.
Archives internationales de pharmacodynamie et de therapie, 265(1), 119-127 (1983-09-01)
The drug CRL 40 028 increases spontaneous motility through an action on central adrenergic receptors. The effects of this drug have been tested in rats on the external pancreatic secretion induced by secretin, CCK, acetylcholine, vagal electrical stimulation or 2
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