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89179

Sigma-Aldrich

L-Threonine

≥99.5% (NT), BioXtra

Synonym(s):

(2S,3R)-2-Amino-3-hydroxybutyric acid

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About This Item

Linear Formula:
CH3CH(OH)CH(NH2)CO2H
CAS Number:
72-19-5
Molecular Weight:
119.12
Beilstein/REAXYS Number:
1721646
EC Number:
200-774-1
MDL number:
MFCD00064270
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57653332
NACRES:
NA.26

product name

L-Threonine, BioXtra, ≥99.5% (NT)

product line

BioXtra

Quality Level

100

assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D −28.5±0.5°, c = 5% in H2O

impurities

≤0.5% foreign amino acids

ign. residue

≤0.1%

loss

≤0.1% loss on drying, 20 °C (HV)

color

white to off-white

mp

256 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤500 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

C[C@@H](O)[C@H](N)C(O)=O

InChI

1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

InChI key

AYFVYJQAPQTCCC-GBXIJSLDSA-N

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Application


  • Reconstruction the feedback regulation of amino acid metabolism to develop a non-auxotrophic L-threonine producing Corynebacterium glutamicum.: This research utilizes L-Threonine as an internal standard for the detection and optimize the production of L-Threonine on genetically modifying Corynebacterium glutamicum aiming at more sustainable and cost-effective bio-manufacturing processes (Liu et al., 2024).

  • Threonine dehydrogenase regulates neutrophil homeostasis but not H3K4me3 levels in zebrafish.: This research utilises L-Threonine as a chemical treatment to study the enzymatic activity of threonine dehydrogenase in regulating neutrophil function in zebrafish (Li et al., 2024).

Other Notes

Preparation of threonine-sepharose, assay and purification of protein kinase C; Amino acid spacing in isotachophoresis on polyacrylamide gel - a critical evaluation; Growth requirement of various microorganisms.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CRC Handbook of Microbiology, 4, 1-1 (1974)
T. Hine et al.
Electrophoresis ?83, 541-541 (1984)
Assay and purification of protein kinase C.
T Kitano et al.
Methods in enzymology, 124, 349-352 (1986-01-01)
Amino acid spacing in isotachophoresi; on polyacrylamide gel: a critical evaluation.
N Y Nguyen et al.
Analytical biochemistry, 94(1), 202-210 (1979-04-01)
Yongxian Zhuang et al.
PloS one, 9(9), e108444-e108444 (2014-09-26)
Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasingly cytotoxic to cancer
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