68138
Transketolase from E. coli
≥0.1 U/mg
Synonym(s):
Glycolaldehyde Transferase
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
Recommended Products
biological source
Escherichia coli
form
powder
specific activity
≥0.1 U/mg
storage temp.
−20°C
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Biochem/physiol Actions
Transketolase is highly specific for ketol donor substrates and is stereospecific and enantioselective to hydroxyaldehyde substrates with an (R) configuration. It specifically catalyzes the irreversible transfer of one ketol unit from α-hydroxypyruvic acid to an aldehyde to produce a D-threo(3S,4R)ketose.[3]
Unit Definition
1 U corresponds to the amount of enzyme which will produce 1 μmol of glyceraldehyde-3-phosphate from xylulose-5-phosphate per minute at pH 7.7 and 25 °C, in the presence of ribose-5-phosphate, thiamine pyrophosphate and Mg2+
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Grégory Simon et al.
Bioorganic & medicinal chemistry letters, 19(14), 3767-3770 (2009-06-19)
Probes were developed for the in vivo detection of transketolase activity by the use of a complementation assay in Escherichia coli auxotrophs They combine the d-threo ketose moiety recognised by transketolase and the side chain of leucine or methionine. These
Chemoenzymatic Synthesis of 5-Thio-D-xylopyranose
F. Charmantray et al.
European Journal of Organic Chemistry, 24, 5526-5532 (2006)
Rajesh K Srivastava et al.
Journal of industrial microbiology & biotechnology, 39(8), 1227-1243 (2012-03-23)
The metabolic reaction rate vector is a bridge that links gene and protein expression alterations to the phenotypic endpoint. We present a simple approach for the estimation of flux distribution at key branch points in the metabolic network by using
Cristian Obiol-Pardo et al.
PloS one, 7(3), e32276-e32276 (2012-03-10)
Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold, found
Khanh vinh quoc Lu'o'ng et al.
American journal of Alzheimer's disease and other dementias, 26(8), 588-598 (2012-01-06)
Alzheimer's disease (AD) is the most common form of dementia in elderly individuals and is associated with progressive neurodegeneration of the human neocortex. Thiamine levels and the activity of thiamine-dependent enzymes are reduced in the brains and peripheral tissues of
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